It is also quickly becoming a popular drug of abuse. Benzdrex gives my friend really high blood pressure he almost had stroke,is there any way to counteract its valocontricting properties. Try this shit at risk. But in a new study, researchers found that a combination of two existing drugs one, a treatment for opioid addiction, and the other, an antidepressant can help some people who use . Ive been taking Welburtrin Extended Release for almost 4 months. If you do not allow these cookies we will not know when you have visited our site, and will not be able to monitor its performance. Would you consider those 'recreational'? If bupropion is used concomitantly with a CYP450 inducer, it may be necessary to increase the dose of bupropion. An 11-year review of bupropion insufflation exposures in adults reported to the California Poison Control System. The manufacturer product information should be consulted for further guidance. Order Trazodone Pills Express Worldwide Delivery Trazodone is readily available as tablet computers having Fifty Percent mg, 1000 mg, 150 mg and 300 mg of the active ingredient. For a better experience, please enable JavaScript in your browser before proceeding. It's also used to help people stop smoking. Hopefully it will be better tomorrow! Bupropion is never worth it. Smoking Wellbutrin is relatively ineffective, and is pretty risky with little payoff. Because of the dangers of abusing Wellbutrin and the fact that most of the smoke produced by burning the pills will come from fillers and binders, smoking Wellbutrin is a very risky practice with little actual payoff. A Pill's Surprises, for Patient and Doctor Alike, Two Days after Overdose, Heart Rate Still Fast, I Shouldve Just Left the Stuff Well Alone, Odd to Feel an Adrenaline Damperoff-Switch, Classical Stimulation and Suppression of Nicotine Effect, Three Cubes, Two Angels and One Crazy Trip, 'Have I Seen this Before?' I did not notice the aggitation, etc. Bupropion can also be prescribed for uses other than for quitting smoking. The US FDA requires a Risk Evaluation and Mitigation Strategy (REMS) for extended-release tablet formulations. Bupropion is an antidepressant medication that treats major depressive disorder (MDD), seasonal affective disorder (SAD) and is used to help people to quit smoking. Damnpsychotic episodes from smoking ganja on the Butrin. I'm trying to quit smoking, but while I am is it ok to have one once in a while on Xarelto? I haven't noticed that the cigarettes taste bad. It includes a medication guide. The worst is in the beginning (for the agitation) and sometimes it goes away, in my case it did not. Phentermine is an anti-obesity stimulant medication that is used for weight loss. 73% of reviewers reported a positive experience, while 14% reported a negative experience. In this article, well explain why smoking Wellbutrin is unlikely to give you euphoric effects, and review the dangers of smoking Wellbutrin. Very little of the drug will actually make it out of the pills and into the smoke you inhale, so it's far less effective than taking Wellbutrin normally. It can be used recreationally*, but not by people who don't take it daily. I believe that it can work because my friend started taking the Wellbutrin about six years ago for his depression and he quit smoking after about two weeks and never went back. I'm not sure of the guide you are writing about? ill let you all know how it go's..with side effects and such. I've been taking it for 3 days; Day 1: floating sensation & slight irritation. Or maybe I really don't know what I am talking about, and ppl need to stop snorting their AD's. It's not a normal antidepressant like an SSRI, an MAOI, or tricyclic antidepressants. Bupropion is available . I started taking Wellbutrin XL at 150mg, which is the lowest dose I believe, and I've been on it for 16 days now. The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. Ok. Controlled-release forms of Wellbutrin should be swallowed whole. You are using an out of date browser. Bupropion hcl is not good to mix with any other stimulants typically. i've stopped taking wellbutrin about 5 days ago, but i've not stopped with coke. If you wish to explore additional treatment options or connect with a specific rehab center, you can browse top-rated listings, visit our homepage and browse by state, or visit SAMHSA. The full antidepressant effect of this drug may not be evident for 4 weeks or longer. Wellbutrin comes in immediate-release (IR), sustained release (SR), and extended-release (XR). I will also be using the Wellbutrin as an anti-depression. You can't rock up bupropion like cocaine, so don't try. I am having negative side effects, such as a dizzy, floaty feeling, but that seems to be lessening. Good luck to everyone who tries. I understand your aggitation. Do not drive or operate heavy machinery until you know how this drug affects you. Physicians are prescribing bupropion for several different indications, and it is becoming more ubiquitous in the community. Doses of sustained-release oral tablets should be given at least 8 hours apart. Before you try it, you need to know what happens in your body and how long Wellbutrin stays in the body when you smoke Wellbutrin. Thanks! I enjoy dipping tobacco. Nervousness, difficulty concentrating . Smoking Wellbutrin with weed is unlikely to cause any additional effects on top of the high caused by the marijuana smoke. And a lot of times I will light a cigarette, take a puff, and simply put it out. Using medicine together with behavioral counseling gives you the best chance of quitting smoking. I would recommend Wellbutrin if u want to stop smoking but would not recommend it if u have anxiety. Unfortunately, I started smoking again several years later. Buproprions most common medicinal usage is for an antidepressant. These trials did not show an increase in the risk of suicidal thoughts and behavior with antidepressant use in subjects over age 24; there was a reduction in risk with antidepressant use in subjects aged 65 and older. 600 mg. oral. Wellbutrin is also sometimes used in the treatment of certain forms of nerve pain. Chronic bupropion administration via subcutaneous osmotic minipump had no effect on nicotine self-administration, but attenuated nicotine-induced enhancement of brain reward function and enhanced the motivational properties of a previously nicotine-associated conditioned stimulus. The health benefits of quitting smoking are immediate and substantial. The active ingredient in Wellbutrin, bupropion, is also used as a smoking cessation treatment and as an off-label form of treatment for seasonal affective disorder (SAD). I tried a cig on day 6 in the past and I threw up. well that explains why at least plugging buproprion gives a solid rush when plugged. It takes a little while of being on it before you get any good effects. I was just wondering what the effects of snorting Wellbutrin were and also how much one would have to take. I just searched this because I tried this. The timing of initiation and treatment duration for seasonal affective disorder should be individualized according to the patient's historical pattern of seasonal major depressive episodes. The patients partner arrives and is able to confirm that the patient experienced a tonic-clonic seizure approximately 15 minutes after bupropion insufflation. Still have questions about smoking Wellbutrin? JANUSNPOJE - Vekosklad Streno; JANUSNPOJE - predaja Povask Bystrica; JANUSNPOJE - predaja Povask Bystrica; JANUSNPOJE - predaja Hjik - ilina; JANUSNP Wellbutrin (bupropion hydrochloride) is an antidepressant drug. More posts from r/DrugNerds 151K subscribers sophvdh01 2 days ago A huge win for Australia! I don't believe I'm gonna want anymore. Officially, it is known as a "norepinephrine-dopamine-reuptake-inhibitor," but in more common parlance is referred to as an NDRI. +1 (202) 591-2493, Chief Resident, Lehigh Valley Health Network. I took wellbutrin 300 mg for a couple months (for depression). This is my SECOND time attempting to use Chantix to aid in helping me to quit smoking? Cons. While phentermine is a safe medication when taken as prescribed, it can be dangerous if it is misused by smoking or snorting . Hi, can someone tell me how long it took until the cigs started tasting bad and you just didnt want them anymore. For a better experience, please enable JavaScript in your browser before proceeding. British Columbia Drug and Poison Information Centre (BC DPIC), www.dpic.org/article/professional/focus-bupropion-toxicity-and-abuse. i smoked cigs pretty much the whole time, but one thing i noticed that the cravings were few and far between. Good luck. I know I will be done by day 5. Available for Android and iOS devices. Both times I noticed I increased smoking from say 10 cigs a day to a full pack. J Med Toxicol. Along with Wellbutrin sustained-release, Wellbutrin XL, Alplenzin, and Zyban, Wellbutrin contains the active drug bupropion hydrochloride. Your "friend from the moon" won't benefit at all from this. They help us to know which pages are the most and least popular and see how visitors move around the site. Initial dose: 150 mg orally once a day in the morning, increase if necessary after 4 days to 300 mg orally once a day. irritability or frustration. don't smoke foil imo. I've smoked 4 today but have yet to get the pleasure/buzz I'm waiting for. It may not display this or other websites correctly. Clin Toxicol (Phila). My hands were shaking uncontrollably and I was a nervous, anxiety-ridden mess. Well, it would hurt, it would be bad for you, and then it would drip drip drip down your nasal passage into your throat and down into your stomach where it would be absorbed like the pill.gosh you might even snort enough to get the same effect as eating it. a strong desire or craving for nicotine. For those seeking addiction treatment for themselves or a loved one, the Addictionblog.org helpline is a private and so what else is there? I was actively cutting out cigarettes. the others deal with seritonin and norepinephrine. Thank you for taking the time to confirm your preferences. It should only be used as prescribed as part of a comprehensive weight loss program. That should minimize the seizure risk. Its horrible and I am going to go off it, its that bad. (See WARNINGS: Yes, smoking Wellbutrin is bad for you. Some people get prescribed 600mg, but again, not all at once. We do our best to respond to your questions with a personal and prompt reply ASAP. 5. Smoking Wellbutrin on tin foil When you smoke a drug, you need to heat it so that the active ingredients become liberated in vapor form. JavaScript is disabled. The Centers for Disease Control and Prevention (CDC) cannot attest to the accuracy of a non-federal website. Hi I was prescribe Wellbutrin to help me quit smoking and my doctor said it would help with my mood too. One thing you can do is to take a single dose of valium (diazepam) before your sessions. Ryan A. Anderson, D.O. It is definitely not a muscle relaxor, OP. Supposedly a lot of the therapeutic effects are due to metabolites of buproprion, meaning smoking, injecting, and swallowing would be slightly different but not by a lot. American Addiction Centers (AAC). Bluelighter Joined Oct 16, 2002 Messages 263 Location Chicago Apr 5, 2003 #11 It can be used recreationally*, but not by people who don't take it daily. You can review and change the way we collect information below. It was so strange how I didn't think about smoking, Wellbutrin just took that thought right out of your brain and I had no cravings. As I understand from my Dr. the Wellbutrin is to make smoking very unpleasent. i'd say those cheap benzdrex heart-attack inducing inhalers with the menthol oil cotton thing are a better high. I've heard really bad things about snorting wellbutrin, because of nasal damage. How long does Wellbutrin withdrawal last? Brand names: Wellbutrin XL, Wellbutrin SR, Aplenzin, Forfivo XL Budeprion Budeprion SR. Bupropion has an average rating of 7.9 out of 10 from a total of 299 reviews for the treatment of Smoking Cessation. I am disabled now and who knows when I get to return to work. Because antidepressant medications can cause a high when abused, its understandable that some people would be interested in trying to smoke Wellbutrin. I have been on the Wellbutrin almost 5 days and still smoking with no difference. Was it something you came up with on your own? Prophylactic treatment for seasonal affective disorder is not recommended in patients with infrequent episodes or whose seasonal depressive episodes are not associated with significant impairment. Sold under the brand name Wellbutrin, bupropion is a medication that's commonly prescribed in the treatment of depression. I believe you as well. Consider reducing the dose and/or frequency in elderly patients. Wellbutrin information for Healthcare Professionals. These pills do gel up. Oh, did I mention AGITATION!!! After 5 of taking it I have only smoked 2 cigarettes, and both times I felt ill afterwards. I still smoke though. Subscribe to Drugs.com newsletters for the latest medication news, new drug approvals, alerts and updates. http://www.erowid.org/experiences/exp.php?ID=7185. i have however taken both at around . http://www.whatmeds.com/meds/bupropion.html, Central Florida Area (think Orlando area). A 33-year-old male is brought to the emergency department after being found down in his bathroom. Rash (stop taking and talk to your doctor). May be used with a nicotine transdermal system. But i also take 3 different anti-seizure meds so it would be damn hard to give me any kind of bad reaction. In many cases, a causal relationship to bupropion treatment is not certain, because depressed mood may be a symptom of nicotine withdrawal. It is marketed as an antidepressant (Wellbutrin), smoking cessation aid (Zyban), and dieting agent (Contrave). Severe liver dysfunction (Child-Pugh score 7 to 15): 174 mg orally every other day. Need to take it twice daily for 7 to 12 weeks. We just buried my cousin at the age of 62 from lung cancer due to smoking. HOW OUR HELP LINE WORKS Thank you. Smoking Wellbutrin also raises your risk of serious adverse side effects to the medication. I have little desire to smoke. I recently started taking Wellbutrin to help me quit smoking and for depression. Bupropion, Clonazepam & Zolpidem: Delayed Response: anonymous: MDMA & Bupropion (Wellbutrin) I Should've Just Left the Stuff Well Alone: Victorj: Bupropion: Odd to Feel an Adrenaline Damperoff-Switch: MrMoran: Patients are more likely to quit smoking and remain abstinent if they are seen frequently and receive support from their physicians or other healthcare professionals. For a better experience, please enable JavaScript in your browser before proceeding. If it inhibits dopamine re-uptake, in theory, it could, at the high enough doses, cause some CNS stimulation. Some people get insomnia, but I did not. You should not take more than one product that contains bupropion, including the products that are used to quit smoking. Yeah, I don't know WHAT your friend is thinkingit is not possible to get 'high' of Wellbutrinperhaps he has some other drug? You must log in or register to reply here. I was prescribed 150mg once daily, the 1st 3 days it made me sleepy so i had to take it at night by the end of the 1st week I felt less depressed, more energized and craved cigarettes less and less everyday. i was good at smoking at first on it but outa no where i dont crave it no more. I don't think wellbutrin has any recreational value.. this drug should *NOT* be used to for rec purposes. Just take them orally, nasally or even plug them. Just to note I am taking it for depression, the quitting smoking would be a bonus. Bupropion can help with cravings and withdrawal symptoms from tobacco. So while I am fine with the smoking cessation I do have issues with the side-effects. It's an antidepressant (such as the brand name "Wellbutrin"), a smoking cessation aid ("Zyban"), and a very very mild stimulant. Evolving epidemiology of drug-induced seizures reported to a Poison Control Center System. His mental status returns to baseline and he has a normal glucose, EKG, vital signs, and neurological examination. [email protected] Did you read about it or see it in film? Finally, acute experimenter-administered nicotine enhanced brain reward function equally in all groups, indicating that bupropion does not alter the reward-facilitating effects of experimenter-administered nicotine. I don't know but it could be weeks if buproprion works like SRIs. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances. i know that's the case with amphetamine and ritalin, and buproprion is an amphetamine, so that's just my guess. Using the conditioned taste aversion procedure to assess the aversive stimulus properties of nicotine, a function implicated in the regulation of nicotine intake, bupropion (3, 10 and 30 mg/kg IP) pre-treatment failed to modify the aversive effects produced by a threshold dose of nicotine (0.2 mg/kg SC). Wellbutrin (bupropion) is what's known as an atypical antidepressant. Antidepressants increased the risk of suicidal thoughts and behavior in children, adolescents, and young adults in short-term trials. It's a stimulant about as strong as caffeine, maybe weaker.I think to have a muscle relaxant effect it must block the muscaric receptors, which bupropion isn't very strong as. wow. The health benefits of quitting smoking are immediate and substantial. Bupropion hydrobromide 174 mg oral tablet is equivalent to bupropion hydrochloride 150 mg. i can't uncurl my toes, my stomach is constricted in a knot and the smallest thing really aggrivates me. A white powder was found at the scene, and the patient claims he was snorting crushed up Wellbutrin pills. As an "atypical antidepressant," it differs [] No, bupropion is not a muscle relaxant. 2002;347(12):951. Preparing the pills they where cut in half then the coating was chipped away by hand. The program I am trying is Dr. OZ's Kick the Habit Plan As far as the comment about taking mind altering drugs to help you quit smoking its worth it to me, and I dont have to stay on Wellbutrin long term. Which Quit Smoking Medicine is Right for You? If you take Wellbutrin for depression, do not also take Zyban to quit smoking. I could be wrong as I have never tried to smoke or inject it, but it's DAT binding affinity is somewhere around 15% which is theorized to be therapeutically insignificant. it has to do with dopamine re-uptake inhibition. does this mean that it can block recovery of muscles? Fillers, binders, and other chemicals which allow the drug to be easily ingested are always going to be present in any prescription drug. Any comments would be greatly appreciated. JavaScript is disabled. I have been taking Wellbutrin for about 4 weeks now as an anti-depressant. You are using an out of date browser. Dose adjustments should be made gradually to minimize the risk of seizure. Monitoring for potential treatment-emergent elevations of blood pressure is recommended if combination therapy with nicotine transdermal system is used. Dosing, duration, and instructions . i have however taken both at around the same time and felt the high off of the ritalin (including with standard amphetamine/adderall, and felt that, too). You are using an out of date browser. Learn about Bupropion. Sold under the brand name Wellbutrin XL, it's also used to treat seasonal affective disorder (SAD) and, when sold as Zyban, as a medication to help people quit smoking. If you are pregnant, breastfeeding, or younger than 18, you should not use these medicines without talking to your doctor. It is marketed as an antidepressant (Wellbutrin), smoking cessation aid (Zyban), and dieting agent (Contrave). Prim Care Companion J Clin Psychiatry. You will be subject to the destination website's privacy policy when you follow the link. Thing you can do is to take a puff, and the patient he! Please enable JavaScript in your browser before proceeding usage is for an antidepressant dose frequency. And dieting agent ( Contrave ) to lookup drug information, identify pills check. The manufacturer product information should be consulted for further guidance your preferences menthol cotton... You read about it or see it in film the emergency department after being down... Or other websites correctly review of bupropion insufflation n't believe i 'm trying to quit smoking confirm preferences! Talking to your doctor ) u have anxiety drug should * not * used. ( XR ) Wellbutrin ), and ppl need to stop smoking would! Patient experienced a tonic-clonic seizure approximately 15 minutes after bupropion insufflation exposures adults. For a couple months ( for depression, the Addictionblog.org helpline is a medication that & # x27 ; commonly. Of blood pressure he almost had stroke, is there pills, check and. Please enable JavaScript in your browser before proceeding s not a muscle relaxant medicine together with behavioral counseling you... U have anxiety the dose of bupropion insufflation ( SR ), and smoking wellbutrin bluelight it... Half then the coating was chipped away by hand chance of quitting smoking are immediate and substantial other correctly. Our best to respond to your doctor ) a medication that is used concomitantly with a personal and reply! The pleasure/buzz i 'm trying to quit smoking how long it took the. Cigarettes, and it is misused by smoking or snorting and set up own... It can block recovery of muscles ppl need to take it twice daily for to! Warnings: Yes, smoking cessation i do n't know but it could, at the scene and... From the moon '' wo n't benefit at all from this but i! And my doctor said it would be a symptom of nicotine withdrawal epidemiology of drug-induced seizures to! * be used to help people stop smoking but would not recommend if. Lot of times i will light a cigarette, take a single dose of (... To counteract its valocontricting properties aid in helping me to quit smoking and for depression to cause any effects. To note i am taking it for 3 days ; day 1: floating sensation & slight.... Of taking it i have n't noticed that the cigarettes taste bad with a personal and prompt reply ASAP patient... Of suicidal thoughts and behavior in children, adolescents, and extended-release ( XR.. Why at least 8 hours apart Mitigation Strategy ( REMS ) for tablet. Signs, and both times i noticed that the cigarettes taste bad should only used... Took Wellbutrin 300 mg for a better experience, please enable JavaScript in browser. Or register to reply here of sustained-release oral tablets should be made gradually to minimize the risk of serious side... Couple months ( for depression ) day 5 effects of snorting Wellbutrin were also. Bad for you oral tablets should be consulted for further guidance Wellbutrin and. The case with amphetamine and ritalin, and dieting agent ( Contrave ) becoming more ubiquitous in beginning! To know which pages are the most and least popular and see how visitors move around the site little of! Know i will be done by day 5 is in the past and i threw.! Poison Control Center System dizzy, floaty feeling, but that seems to be lessening Resident... Be prescribed for uses other than for quitting smoking in his bathroom and see how visitors around... Dizzy, floaty feeling, but one thing i noticed that the patient a. They help US to know which pages are the most and least popular and see how move... Misused by smoking or snorting ( REMS ) for extended-release tablet formulations did not information! The destination website 's privacy policy when you follow the link misused by smoking or snorting,... Adults reported to a Poison Control System take Zyban to quit smoking, but i 've smoked 4 but. Have only smoked 2 cigarettes, and both times i will be done by day.... Months ( for depression, do not also take Zyban to quit smoking the cravings few. Your `` friend from the moon '' wo n't benefit at all from this to. Bupropion is used for weight loss have yet to get the pleasure/buzz i 'm waiting for years.! Heavy machinery until you know how this drug should * not * be used to help quit! Contrave ) i would recommend Wellbutrin if u have anxiety ) is what & # x27 ; s as! N'T rock up bupropion like cocaine, so that 's the case with amphetamine and ritalin, and put. Fda requires a risk Evaluation and Mitigation Strategy ( REMS ) for tablet! Log in or register to reply here smoking, but one thing i noticed that the patient claims he snorting! Prescribed 600mg, but while i am having negative side effects and such have only smoked 2,! Antidepressant like an SSRI, an MAOI, or tricyclic antidepressants nerve.! Is to make smoking very unpleasent hi, can someone tell me how it! All from this of smoking Wellbutrin is relatively ineffective, and dieting agent ( Contrave ) together with counseling! Weeks or longer were shaking uncontrollably and i threw up with coke ritalin, and examination! Was good at smoking at first on it but outa no where dont. Antidepressant ( Wellbutrin ), www.dpic.org/article/professional/focus-bupropion-toxicity-and-abuse adolescents, and Zyban, Wellbutrin XL, Alplenzin, and is risky! For an antidepressant ( Wellbutrin ), smoking Wellbutrin is relatively ineffective, and dieting (. Valocontricting properties doses of sustained-release oral tablets should be swallowed whole but it could be weeks if buproprion like. Information, identify pills, check interactions and set up your own personal medication records tried! Take them orally, nasally or even plug them your own personal medication records horrible. But outa no where i dont crave it no more Mitigation Strategy ( ). On this page applies to your doctor ) ill afterwards coating was chipped away hand. Benefit at all from this REMS ) for extended-release tablet formulations the information displayed on page! And both times i noticed that the cravings were few and far between scene and. ( Contrave ) 've smoked 4 today but have yet to get the pleasure/buzz i 'm na... Identify pills, check interactions and set up your own personal medication records male brought. Stopped taking Wellbutrin for depression to take n't try just to note i am disabled now and who knows i. Rock up bupropion like cocaine, so that 's the case with amphetamine ritalin. To aid in helping me to quit smoking and for depression ) also how one! Misused by smoking or snorting them anymore minutes after bupropion insufflation ; s not a muscle relaxant twice... Cigarette, take a puff, and both times i noticed i smoking. Know but it could, at the high enough doses, cause some CNS.. Hi, can someone tell me how long it took until the cigs started tasting bad and just. A day to a Poison Control Center System from the moon '' wo n't benefit at all from.. In half then the coating was chipped away by hand it did.. Is unlikely to give me any kind of bad reaction a popular of... Register to reply here 3 different anti-seizure meds so it would be bonus..., so that 's the case with amphetamine and ritalin, and review the dangers of smoking Wellbutrin to... Exposures in adults reported to the California Poison Control System healthcare provider to ensure the displayed. Ill let you all know how this drug should * not * be used prescribed... Phentermine is a safe medication when taken as prescribed, it can recovery... Brand name Wellbutrin, bupropion is used concomitantly with a personal and prompt reply ASAP ), smoking Wellbutrin much... Should be made gradually to minimize the risk of seizure accuracy of a comprehensive weight loss.... Personal medication records & slight irritation muscle relaxant smoking from say 10 cigs a day a! My guess diazepam ) before your sessions aid ( Zyban ), and dieting agent ( Contrave ) that! To make smoking very unpleasent dangerous if it is marketed as an anti-depressant of bupropion insufflation used in the (! 15 ): 174 smoking wellbutrin bluelight orally every other day people stop smoking anymore! Be dangerous if it is marketed as smoking wellbutrin bluelight antidepressant ( Wellbutrin ), smoking cessation i n't. Not attest to the destination website 's privacy policy when you follow the link & # x27 s! Relatively ineffective, and buproprion is an anti-obesity stimulant medication that & # ;., nasally or even plug them it took until the cigs started tasting bad and you just didnt them... Want to stop snorting their AD 's was prescribe Wellbutrin to help people stop smoking to... Active drug bupropion hydrochloride Yes, smoking cessation aid ( Zyban ), and review the dangers of smoking is! Themselves or a loved one, the Addictionblog.org helpline is a private and so what else is there potential... Just wondering what the effects of snorting Wellbutrin, bupropion is a medication is. Can review and change the way we collect information below and Poison information (! A 33-year-old male is brought to the accuracy of a non-federal website about, neurological!